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Monday Night Football Week 10 TV Schedule, Odds And Picks

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The New York Giants and San Francisco 49ers are set to finish up Week 10 of the 2018 NFL season with a Monday Night Football clash. These teams are both well outside the playoff hunt at this juncture, making for a rather unimportant nationally televised contest. One way to ramp up the excitement is to have a wager on the outcome, putting some meaning into a matchup that may actually be better for the teams on the field to lose in order to help secure a better position in the upcoming draft.

Oddsmakers are projecting the Niners to win, installing the squad as a 3.5-point favorite. The home side is coming into Week 10 on the heels of a convincing primetime victory last week, getting an incredible debut from former practice squad quarterback Nick Mullens in his first career start. Mullens took over for incumbent signal-caller C.J. Beathard—a player that had his best game as a pro against the G-Men last season—and guided his team to a 34-3 victory over the cross-town rival Oakland Raiders. Beathard won’t get another chance to shine against this foe this year, as San Francisco head coach Kyle Shanahan is electing to give Mullens another starting nod based on his stellar Thursday Night Football performance. He’ll have to outduel two-time Super Bowl champion Eli Manning, who hasn’t played well in 2018. The veteran QB hasn’t lost his job yet, however, despite New York’s 1-7 start to the campaign and a 4-3 touchdown-interception ratio. Manning was responsible for two costly turnovers in last week’s 20-13 defeat to the NFC East leading Washington Redskins, sinking Big Blue to the bottom of the NFL standings.

Will the Giants come up with an upset in hostile territory to nab their first victory since Week 3? Or will the Niners keep it rolling with Mullens again under center on the big stage? Pro handicapper Jon Price of has a take on this Monday Night Football matchup that you will not want to miss. Before seeing who the Vegas expert suggests taking in the Week 10 finale, have a look at the full schedule, start time, TV info, live stream site, updated odds and notable betting trends for the upcoming 49ers-Giants showdown.

Monday Night Football Viewing Guide And Odds

Time (ET) Matchup TV Stream Odds Total
8:15 p.m. San Francisco 49ers vs. New York Giants ESPN WatchESPN SF -3.5 44.5

Odds via BetDSI Sportsbook

New York Giants At San Francisco 49ers Betting Trends

  • New York is 5-12 straight-up in its last 17 away matchups against San Francisco.
  • The total has gone UNDER in six of the Giants last seven night contests.
  • San Francisco is 9-1 straight-up in its last 10 Monday Night Football 
  • The Giants are 1-4 against the spread in their last five games following a bye week.
  • Both the road team and underdog are 4-1 against the spread in the last five meetings between these teams.

New York Giants At San Francisco 49ers Media

Pat Leonard caught up with Odell Beckham, who said he’s close with and rooting for 49ers cornerback Richard Sherman—a player he’ll match up with often tonight—due to their shared perseverance through injury:

The Niners confirmed that Nick Mullens would be the starter tonight and tweeted out the stats from his historic debut:

Kyle Shanahan isn’t surprised that Mullens found tremendous success last week (via Niners Nation):

Like I said last week, Nick’s a machine with every opportunity he gets. He is out there, he is dialed in. He takes advantage of every opportunity. Showed some clips earlier in the week of where he was last year on this exact date on a Wednesday, whatever that date was. We were running a play on the field and it wasn’t him getting the rep because he was at middle-third safety and I was showing him. I was like, ‘How did you get better that day?’ Then, there were clips of him after practice throwing that clip on air. Then, the next clip was a year later to the day and we were running the same play but he was actually playing quarterback instead of safety, or not on a field by himself throwing to air. He always finds a way to get work and he works the same way every day. I’m sure it’s a lot more fun for him and better work that he’s got the other 10 guys out there he’s going to be working with on Monday.

Matt Barrows quoted Kyle Shanahan on how difficult it is to bring down Giants star rookie Saquon Barkley:

PFF Fantasy Football revealed that Eli Manning is averaging more yards per game (297.1) right now than in any other season of his 15-year-career aside from 2011 (308.3):

New York head coach Pat Shurmur won’t be making a quarterback change for this Monday Night Football game (via

[Eli] is starting Monday. You roll with it how you want, with the idea that he’s going to get us on a run here and there will be no decisions to be made. In other words, part of the conversation (with Manning) was, we trust you, we want to work with you, and we trust the fact that you’re going to get in there and help us win football games.

I spoke to Eli a couple times this weekend and I explained to Eli that he’s going to start Monday. I also explained to Eli that everybody needs to play better and as we go through this, it’s important that we’re not ‘almost’ in these games. We do what we have to do to get it over the top and win football games. We’ll just take it from there. But I spoke to the team about that, and then I also spoke to Eli about that specifically.

Jordan Raanan reported that the NFL monitored the fires in the Bay Area and considered postponing or moving the contest:

Covers found that these have been two of the worst teams against the spread in 2018

San Francisco defensive coordinator Robert Saleh praised New York’s top offensive weapons (via NBC Sports)

The Giants have an incredible set of skill players. The tight end, Evan Engram, is really good. Odell (Beckham, Jr.,) is obviously really good. (Barkley) is phenomenal. Well worth the draft pick. Even (wide receiver) Sterling Shepard’s a really good player. So, it’s going to be a great challenge for us this week.

Monday Night Football Week 10 Pick

Pick: Giants +3.5

Prediction: Giants 21 – 49ers 20

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